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CJC-1295 has been marketed with and without drug affinity complex (DAC) technology, which extends its half-life and resultant therapeutic window as follows [2]: CJC-1295 No DAC: CJC-1295 No DAC contains only straight CJC-1295 with a D-Ala at the 2-position, a Gln at the 8-position (to reduce asparagine rearrangement), an Ala at position 15 (to enhance bioactivity), and a Leu at position 27 (to prevent methionine oxidation)

Suggested use: 46 weeks per course, followed by a 2-week break

TABLE 1 Carnitine transporters involved in cancer

The dominant risk category is gastrointestinal, and most adverse events are dose-dependent and transient