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You may start to notice some changes, like reduced appetite or a few pounds lost, within the first few weeks of taking semaglutide

Fatigue and mental fog take longer because they reflect genuine sleep loss and metabolic disruption

However, off-label use does not mean the approach has been proven safe or effective

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Gillespie JR, Bush JR, Bell GI, Aubrey LA, Dupuis H, Ferron M, Kream B, DiMattia G, Patel S, Woodgett JR, Karsenty G, Hess DA, Beier F (2013) GSK-3 function in bone regulates skeletal development, whole-body metabolism, and male life span