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They should be administered by trained clinicians who screen properly first
In clinical trials, patients using injectable semaglutide lost an average of 15% to 16% of their body weight over 64 weeks, while those using an oral semaglutide formulation lost approximately 13%. The difference is meaningful but modest, and for many people the convenience and lower friction of an oral format may more than offset a slightly lower average weight loss
GLP-1 RAs, such as tirzepatide and semaglutide, have become widely used to treat obesity and type 2 diabetes
Researchers do not know all its potential side effects or drug interactions
Hormonal fluctuations, particularly the menstrual cycle in women, can cause regular monthly water retention patterns that completely obscure fat loss for one to two weeks per cycle
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