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More importantly, multifunctional nanoparticles can be designed to simultaneously modulate multiple components of the immunosuppressive TME, reprogram immune cell polarization, and synergize with conventional therapies to elicit durable antitumor immune responses (1618)

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IGF-1 LR3 and the GH-IGF Axis: Where It Fits The GH-IGF-1 axis follows a pulsatile, feedback-regulated architecture