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Under physiological conditions, GSH quenches oxidizing substances (such as reactive hydroxyl free radicals, peroxynitrite, and H 2 O 2 ) directly or reduces hydrogen peroxide (or lipid peroxide (lipid-OOH)) to water (or the corresponding lipid alcohol (lipid-OH)) under the catalysis of GPX (summarized in Fig
Author contributions KH and JB: conceptualization, design of the work, and resources
Symptoms of B12 deficiency B12 deficiency produces symptoms that overlap frustratingly with common tirzepatide side effects : Fatigue and low energy : Often attributed to reduced caloric intake Brain fog and poor concentration : Mistaken for a dietary side effect Mood changes : Depression, irritability, anxiety Tingling in hands or feet : Peripheral neuropathy from B12 depletion Weakness : Often blamed on muscle-related side effects Because these symptoms mirror common GLP-1 side effects, B12 deficiency often goes unrecognized in people taking tirzepatide
doi: 10.2174/1381612828666220620160516 56 ChakrabartiSKGhoshSBanerjeeSMukherjeeSChowdhuryS
Once the medication is stopped, the body needs time to adjust to lower GLP-1 levels or side effects like increased appetite, energy crashes, and weight fluctuations can occur
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