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The mutation of GLP-1 Phe 28 to Ala causes it to lose nearly all of its affinity (IC 50 : 0.27 nM357 nM), and Ile 29 mutation decreases the affinity notably (IC 50 : 0.27 nM25 nM), while Trp 31 , Leu 32 , and Val 33 mutations have little influence, showing that they may be merely subsidiary
This therapy can be excellent for individuals who have trouble absorbing nutrients through the digestive system or who have specific nutrient deficiencies
References Shi M, McHugh KJ
10.3389/fneur.2023.1215618 66
Yuan H, Li X, Zhang X, Kang R, Tang D
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