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Reconstitution must be performed with bacteriostatic water (0.9% benzyl alcohol)

Figure 2: Pycnogenol improves skin elasticity and prevents moisture decrease Another finding that supports Pycnogenols positive effects on skin barrier function was the increased expression of genes involved in keratinocyte differentiation and barrier formation, including loricrin, indicating that Pycnogenol supplementation was associated with improved formation of cornified envelopes and, thus, preserved skin hydration by reducing trans-epithelial water loss

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This observation, combined with evidence that older adults have blunted MOTS-c responses to exercise, supports the hypothesis that declining mitochondrial peptide signaling contributes to the reduced exercise adaptability seen in aging

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