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The cryo-EM structure shows that orforglipron stabilizes a unique conformation of TM1 and TM2 that differs from both the inactive receptor state and the peptide-bound active state

Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice

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Molecular Cancer , 24 (1), 307 Liu, C., Ji, L., Hu, J., Zhao, Y., Johnston, L