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When the retinal blood supply is compromised, essential oxygen and nutrients fail to reach the eye, leading to cell damage, vision loss, and in severe cases, complete blindness
When in the reduced state, GSH is active and protects cells and DNA by neutralizing reactive oxygen species, such as naturally occurring peroxides and free radicals produced during metabolism that could otherwise damage cellular components
Furthermore, a recent extensive cohort study involving over 33,000 GLP-1 RA users diagnosed with diabetes over a 9-year period indicated no significant increase in pancreatic cancer risk associated with GLP-1 RA use, as evidenced by an HR of 0.50 compared to basal insulin [60]
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