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Dysregulation of copper ions can disturb lipid metabolism, resulting in oxidative stress, mitochondrial damage and endothelial cell dysfunction (14), and induce atherosclerosis and other cardiovascular diseases such as arrhythmia and cardiomyopathy (15)

PLP is involved in several aspects of macronutrient metabolism, histamine synthesis, neurotransmitter synthesis, hemoglobin synthesis, and gene expression [22, 23]

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Schizophrenia: A meta-analysis of NAC augmentation in schizophrenia found significant improvements in total PANSS scores and negative symptoms (Yolland et al., Aust N Z J Psychiatry, 2020) [75]