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The molecules that had an effect were then chemically manipulated to see if the effect could be increased

36 If patients are already close to their glycaemic target before starting GLP-1RAs, the dose of their other antihyperglycaemic medications, especially insulin and sulfonylureas, may need to be decreased at GLP-1RA prescription, to prevent hypoglycaemia

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These early recovery signs can sometimes become more important later if not managed carefully