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Ammonium formate (1 mol/L) and LC/MS-grade formic acid were purchased from Fujifilm Wako Chemical Industries (Osaka, Japan)

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Disruption of UPS function is a central pathogenic feature across a broad spectrum of NDDs

IF I LOOK AT THE LAST 10 YEARS OR EVEN 20 YEARS OF MY LIFE, IM LIKE MY GOD LOOK AT ALL THE STUFF I DID, BUT IF I ZOOM IN TO WEEKS MONTHS EVEN SOME YEARS, I FELT LIKE MAKING PROGRESS WAS COMPLETELY INTRACTABLE, AND IT FELT LIKE I WAS YOU KNOW STUCK IN MUD, BUT WHEN YOU KEEP YOUR FEET MOVING, WHEN YOU ZOOM OUT AND YOU KIND OF GET THROUGH THAT SPOT A LOT OF TIMES, YOU REALIZE OH NO I WAS MAKING PROGRESS