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A review of obesity pharmacotherapy published on NCBI describes a 12-week AOD 9604 trial in which the treated group lost more body fat than placebo without altering glucose control

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PPAR and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale

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Additional evidence suggesting ROS involvement in promotion of adipogenesis comes from antioxidant supplementation experiments where lower levels of ROS resulting from antioxidants contribute to adipose tissue dysfunction and IR [106]