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The resulting peptide has a nearly identical 3D spatial arrangement of functional groups as the originalmaintaining target binding affinitybut is unrecognizable to proteases that cleave L-amino acid peptide bonds

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By addressing these metabolic disturbances, GLP-1 agonists may create a more favourable environment for mental wellbeing

In the SURMOUNT-1 trial, also published in NEJM, participants receiving tirzepatide achieved weight reductions ranging from 16.0% to 22.5% depending on dose over 72 weeks