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It has been demonstrated that Hcy acts as an inducer of oxidative stress rather than directly affecting the enzymatic activity of apyrase (catalyzes the hydrolysis of ATP to yield AMP and pyrophosphate), and that the ROS produced under hyperhomocysteinemia are more likely the true modulators of ADP hydrolysis than the mechanism by which Hcy inhibits the hydrolysis of nucleotides [44]
PubMed, Custodio, Hipolito M., Karin Broberg, et al
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Toxicol Ind Health 32(9):16071618
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