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It was shown that aged or/and damaged RBCs are sequestrated in the hepatic sinusoid in a PS-dependent way, and the human sinonasal epithelial cells (HSECs) mediate the recognition and the binding of damaged RBCs in a PS-dependent manner via stabilin-1 and stabilin-2 (pro-phagocytic signals and ligandligand interactions) [275,276,277]

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This process is called glutathione conjugation

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Persistent, spreading, or blistering reactions are a signal to stop entirely and seek professional evaluation, since these may indicate a true allergy rather than ordinary transient irritation