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Full doses of these medications can cause gastrointestinal issues, such as nausea, vomiting, and diarrhea
Key management considerations include: Continuing prescribed arthritis medications (disease-modifying agents, corticosteroids) as directed Monitoring for new or worsening joint symptoms that may require evaluation Maintaining adequate protein intake (generally 0.8-1.0 g/kg body weight, individualized based on age and kidney function) to preserve muscle mass during weight loss Ensuring sufficient calcium and vitamin D for bone health Reporting severe joint pain, swelling, or functional limitation promptly Patients should seek medical evaluation if they experience sudden onset of severe joint pain, joint swelling with redness or warmth, inability to bear weight, joint symptoms accompanied by fever, or persistent pain lasting more than 6 weeks
Engaging in regular physical activity: Aim for at least 150 minutes of moderate exercise weekly plus strength training to improve metabolic function 24
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This genetic activation triggers the robust expression of phase II detoxifying and antioxidant enzymes, including Heme Oxygenase-1 (HO-1), Superoxide Dismutase (SOD), Catalase (CAT), and Glutathione Peroxidase (GPx)
