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For melanocortin receptor pharmacology and MC4R pathway research, Melanotan-2 provides a valuable nonselective tool

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But these reports are anecdotal

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On the other hand, in case of excessive distress, cells are exposed to high levels of ROS which can cause neuroinflammation, damage to the blood-brain barrier (BBB) and impairment to astrocyte crosstalk leading to ASD (Russo et al., 2018)