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95% CI, 1.412.75) in the CANVAS CVOT, which overall included 10,142 patients with T2DM and high cardiovascular risk [75]
The B12-intrinsic factor complex travels to the terminal ileum, where it binds to specific receptors (cubilin-amnionless complex) and is absorbed through receptor-mediated endocytosis
The downstream consequences extend far beyond blood glucose regulation
More serious but rare adverse effects include pancreatitis, gallbladder disease (cholelithiasis, cholecystitis), and acute kidney injury, which require prompt medical evaluation if symptoms develop
Cold exposure reliably activates BAT, but prolonged cold exposure is impractical for most people
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