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Gln deprivation can enhance the sensitivity of A2780cis cells to cisplatin by promoting the methylation of the GS promoter, inhibiting GS synthesis, and downregulating intracellular GSH levels ( Furthermore, Gln metabolism can also exert epigenetic influences on tumor resistance
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They should not be relied upon and may be subject to change without notice
Follow-up work might move to animal models where histological scoring, imaging, and functional tests allow for more complex observations, always with appropriate controls and ethical oversight
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