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Mutations and damage to mitochondrial DNA can affect the function of oxidative phosphorylation complexes, leading to increased ROS generation

10.2174/1871527316666170328113309 35 BraidyN.ZarkaM.WelchJ.BridgeW

Biomedicines 10 , 1757 (2022)

Methods: We identified and studied metabolites and soluble biomarkers in plasma from LC individuals mainly exhibiting ME/CFS compared to age-sex-matched recovered individuals (R) without LC, acute COVID-19 patients (A), and to SARS-CoV-2 unexposed healthy individuals (HC)

This information is useful in understanding the significance of oxidative stress in the pathogenesis of hypertension in this species