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A key feature of AD and PD is the deterioration of synaptic transmission in the cortex and limbic structures of the brain in AD and the loss of dopaminergic synapses in the nigrostriatal dopaminergic projection in PD

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Also berberine may have side-effects, which can result in an upset stomach and result in diarrhoea

In a second randomized study, berberine resulted in reduced free testosterone, HOMA-IR, and increased sex-hormone binding globulin (SHBG) comparable to metformin [9]

L-Carnitine supplementation can support the liver, blood sugar and cholesterol metabolism, and cardiac function