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Clinical trials suggest that patients who achieve at least 5% body weight loss by months three to four are likely to be long-term responders

Plasma Metabolites Predict Severity of Depression and Suicidal Ideation in Psychiatric Patients-A Multicenter Pilot Analysis

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While this is generally not clinically significant, patients on multiple blood pressure medications should be monitored for hypotension, particularly if initiating magnesium supplementation alongside GLP-1 therapy, which may also contribute to modest blood pressure reductions through weight loss

PubMed , Journal of Alternative and Complementary Medicine (New York, N.Y.) , vol