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For ongoing care, especially if you have a chronic condition causing the deficiency, you might need maintenance shots, maybe every two months or even monthly

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If choosing one time, evening application may be slightly more effective for wrinkle treatment since skin repair processes increase during sleep

Fibroblasts migrate to the tear to initiate collagen deposition and structural reinforcement

Who May Need Extra Caution Extra caution may be needed for patients who are pregnant or trying to become pregnant, have active cancer or a cancer history requiring specialist input, have autoimmune disease, have clotting concerns, use immune-modifying medication, have uncontrolled diabetes, have significant kidney or liver disease, or are scheduled for surgery