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Freezing reconstituted peptides causes ice crystal formation inside the solution, and those crystals physically disrupt the hydrogen bonds that maintain the peptide's tertiary structure

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43 KefasB.GodlewskiJ.ComeauL.LiY.AbounaderR.HawkinsonM.et al (2008)

SLC7A11 is a key component of the cystine/glutamate antiporter system Xc, which imports cystine for GSH biosynthesis