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Notably, this sequence contains non-proteinogenic residues including alpha-aminoisobutyric acid (Aib) and D-amino acids (D-2-naphthylalanine and D-phenylalanine), which are deliberately incorporated to enhance metabolic stability and receptor-binding selectivity
Indeed, differences in segregation of activated GLP-1Rs into these membrane rafts are an important feature of biased agonist action (Buenaventura et al ., 2019)
Pedersen BK, Ostrowski K, Rohde T, Bruunsgaard H: The cytokine response to strenuous exercise
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