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According to the Ozempic SmPC, use is not recommended in patients with severe gastrointestinal disease, including severe gastroparesis

The third embodiment of the present invention provides a process for the preparation of H-Glu(OtBu)-Gly-Thr(tBu)-Phe-Thr(tBu)-Ser(tBu)-Asp(OtBu)-Val-Ser(tBu)-Ser(tBu)- Tyr(tBu)-Leu-Glu(OtBu)-Gly-Gln(Trt)-Ala-Ala-Lys(Boc)-Glu(OtBu)-Phe-Ile-Ala-Trp(Boc)- Leu-Val-Arg(Pbf)-Gly-Arg(Pbf)-Gly-Resin, comprising

After initial education during your consultation, patients will administer the peptide at home through small subcutaneous injections

The most effective technique, the modified Valsalva maneuver, involves sitting upright while blowing into a straw or small tube for 15 seconds

Acknowledgements We are very grateful to Professor Rafael Radi (Montevideo, Uruguay) for his helpful discussions and revision of this manuscript