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Plotted from data in J Am Soc Nephrol 2006
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12 It is contraindicated in women with acute pancreatitis, congestive heart failure, medullary thyroid carcinoma and multiple endocrine neoplasia syndrome type 2 (MEN 2)
How GLP-1s Work in the Body Slow gastric emptying (food stays in the stomach longer) Increase satiety signals to the brain Reduce appetite and overall intake Improve insulin response and glycemic control While these effects support metabolic health, slower digestion is also what sets the stage for GI symptoms, including reflux. Digestive Impact of GLP-1s: What the Research Shows Increased Upper GI Symptoms One of the most consistent findings across GLP-1 clinical trials is the high rate of gastrointestinal side effects
