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Treatment With LY2409021, a Glucagon Receptor Antagonist, Increases Liver Fat in Patients With Type 2 Diabetes
Key Takeaways Zepbound produced greater weight loss in the head-to-head SURMOUNT-5 trial 20.2% vs Wegovys 13.7% Zepbound is a dual GIP/GLP-1 agonist
The peptide reduces production of pro-inflammatory cytokines including IL-1, TNF-, and IL-6 while enhancing expression of anti-inflammatory mediators such as IL-10 and TGF-, creating a cytokine milieu that supports tissue repair rather than ongoing damage
Does this indicate that these receptors are located on the basolateral membrane, thereby being accessible and responsive to changes in circulating concentrations of NEFA
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