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Moreover, H 2 O 2 /O/OH modulate metabolic pathways, such as the tricarboxylic acid cycle and mitochondrial function, thereby indirectly influencing the availability of essential metabolites required for epigenetic enzyme modifications [164]

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double and/or triple PIO combinations, in patients with biopsy-proven NASH and T2D (having no contraindications to receive any of these medications) are crucially anticipated