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In Phase 2 trial imaging, fat mass fell substantially more than lean mass, so most of the weight lost was fat the muscle loss is real but is a minority of total loss and is in the same range as semaglutide and tirzepatide
This is where the answer gets less tidy, because long-term treatment looks different for everyone
For a deeper breakdown of how to choose one, see our guide to the best electrolyte powders
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As we move through 2026, new medications like Retatrutide (a triple agonist targeting GLP-1, GIP, and Glucagon) are completing Phase 3 trials
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