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LADPIs reduce the levels of inflammatory biomarkers such as IL-1, TGF-, total proteins and lower the recruitment of leukocytes and neutrophils (Li et al., 2017)

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The bottom line: These approaches support overall skin health and can complement professional treatment, but they cannot substitute for treatments that actually stimulate collagen production in the skin

So not only do we need to be aware of the acceptable lower limit, but also the acceptable upper limit which is currently not well defined