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p53-pS15 is a major focal point in p53 activation to mediate p53-dependent transcription or growth arrest, Ser 15 phosphorylation triggers a sequence of additional sites phosphorylation in p53 (including Ser9, -20, -46 and Thr18) that contribute further to p53 activation 28

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It achieves this by increasing the expression of important proteins such as GPX4 and SLC7A11, as well as activating the Keap1-Nrf2/HO-1 signaling pathway [54]

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