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The association of incretin-based therapy with thyroid cancer originates from preclinical data showing the elevation of calcitonin and occurrence of hyperplasia and tumors arising from rat thyroid gland parafollicular C cells after treatment with liraglutide, a GLP-1R agonist [18,19,20]

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Patients should be counseled to distribute fluid intake throughout the day rather than consuming large volumes at once, and to increase intake during hot weather or physical activity

Interestingly, a subset of patients in these trials were also treated with SGLT2 inhibitors

Atherosclerosis emerges as the invisible killer lurking in the cardiovascular system