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In 2024 the Food and Drug Administration added cardiovascular risk as a reason to be prescribed the GLP-1 drug Wegovy, grounded in results from a major trial that showed fewer heart attacks, strokes, and cardiovascular deaths in adults with obesity or overweight and established heart disease
The results of flow cytometry also demonstrated that, as detected by Annexin staining, FOXO4-DRI treatment significantly promoted apoptosis in senescent cells (Figure 6E)
The molecular and structural/functional changes translate to (1) Tubular atrophy, podocyte hypertrophy, glomerulosclerosis, and microvascular rarefaction and (2) glomerular basement membrane thickening, nephrosclerosis, and extracellular matrix accumulation, respectively [84]
All in all, the placebo group fared far worse than those on orforglipron
The key is finding the balance between beneficial vitamin D synthesis and triggering heat-related flares
