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5.4 Gastrointestinal Side Effects and Nutrient Loss Nausea and vomiting are well-documented adverse effects. Persistent vomiting or diarrhoea may: Increase electrolyte loss Reduce caloric intake Reduce dietary diversity However: These effects are typically transient and dose-related

The proportion of patients who were persistent with semaglutide was 45.8% versus 35.6% in patients receiving liraglutide

Last but not least, by reducing the dose and avoiding systemic distribution, nasal delivery of GLP-1 drugs should alleviate gastrointestinal and other adverse events, offering a promising approach for maximizing the therapeutic effects GLP-1 drugs with potentially increased compliance and safety

Use this guide to help determine if you are using B12 correctly and how to inject B12 correctly

Eur Heart J 2025