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The mechanisms by which these drugs act are not fully understood but likely involve numerous biochemical pathways related to metabolism, appetite, and inflammation, raising the possibility of a variety of effects beyond (and independent of) reduction of energy intake and blood glucose levels

Chilton FH

Due to the limited research on microdosing, the body's long-term response to these reduced doses remains unpredictable

If a patient starts on semaglutide and plateaus, their physician can evaluate whether switching to tirzepatide makes sense

they represent a step change in what outpatient weight management can achieve