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Pang L, Lian X, Liu H, Zhang Y, Li Q, Cai Y, et al
The interplay between gut hormones and neurological pathways could unveil new insights into appetite regulation and obesity treatment
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Patients should carefully consider the risks and benefits of these medications with their healthcare provider to determine the most appropriate treatment option
Exendin-4-stimulated GLP-1R triggers VAPB-localised cAMP generation and PKA activity at the outer mitochondrial membrane As stated above, besides VAPB, our interactome analysis highlighted several factors enriched for their association with active GLP-1R localised at the ER, mitochondria and/or ERMCSs, a location where VAPB plays a prominent organising role 17 , suggesting that ERMCSs could be a potential hub for endosomal GLP-1R signalling
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