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The cardiovascular safety and efficacy of tirzepatide in adults with T2D has been assessed in a large phase 3 clinical trial (SURPASS-CVOT) (Table 1) [88]

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Together, these effects support weight loss by reducing calorie intake and improving metabolism

[26] [27] Ultimately, treatment decisions should be made collaboratively, based on current evidence, regulatory approvals, and individualised assessment of benefits and risks

In addition, AF triggered autophagy-dependent ferroptosis by blocking intracellular iron trafficking and storage to destroy iron homeostasis in human glioma, which was related to the activation of AMPK/mTOR/p70S6K signaling (Chen G