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For patients without absorption disorders, high-dose oral supplements of 1,000 to 2,000 mcg daily have been shown to be comparably effective at correcting mild to moderate deficiency at lower cost and greater convenience.

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Though in vitro data and in vivo animal data thus far is promising, more information and human trials are needed to evaluate the potential role of methylene blue as a treatment for acute and chronic brain injuries

Changes of 10% or more represent meaningful progress

Liver protection: the acetaminophen connection NAC is the FDA-approved antidote for acetaminophen (Tylenol) overdose