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This, according to Parnacott, is largely due to its dual-action mechanism. Developing a medication that targets two distinct pathways in the body required a more complex production process, extensive clinical trials, and significant research investments, he explains

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But they transformed a peptide with a 20-minute half-life into one that circulates for 20 to 30 hours

Novo Nordisk has also cited indirect comparison data suggesting that fewer patients discontinued oral semaglutide due to side effects compared with orforglipron, though the companies and independent commentators note the significant methodological limitations of such comparisons in the absence of a head-to-head obesity trial