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Moreover, in DNA methylation alterations of tumor cells induced by GLP-1RAs, studies have demonstrated that during breast cancer progression, tumor suppressor genes such as ESR1, CDH1, and ADAM33 are downregulated due to hypermethylation alterations in their promoter regions
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30 ) by the central laboratory at screening
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IGF-1 is produced throughout ones lifespan, typically peaking around puberty (6)
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