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Rather than blocking reuptake to keep serotonin in the synapse longer, GLP-1 agonists appear to enhance the overall activity of serotonergic neurons

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Administering a GLP-1 agonist affects multiple organs simultaneously, explaining secondary benefits like reduced appetite, cardiovascular improvements, and kidney protection

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M1 macrophages, in both mice and humans, rely upon glucose-based metabolism, particularly the PPP, to produce nucleotide precursors and NADPH (82, 79)

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Slowly tapering the GLP-1 medication after reaching the higher dose to maintain the effects

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