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During the study, the study d A Research Study to Compare Two Types of Insulin: Insulin 287 and Insulin Glargine in People With Type 2 Diabetes Who Have Not Used Insulin Before Intervention 1 Intervention 2 Not provided Anticipated Start Date Not provided Actual Start Date 2019-05-09 Anticipated Date of Last Follow-up 2021-03-05 Estimated Primary Completion Date Not provided Estimated Completion Date Not provided Actual Primary Completion Date 2019-12-12 Actual Completion Date 2020-01-17 Age Cohort Genders Accepts pregnant individuals Unspecified Accepts lactating individuals Unspecified Accepts healthy individuals No Inclusion Criteria: * Male or female, aged 18-75 years (both inclusive) at the time of signing informed consent * Diagnosed with type 2 diabetes mellitus greater than or equal to 180 days prior to the day of screening * HbA1c of 7.0-10.0% (53.0-85.8 mmol/mol) (both inclusive) as assessed by central laboratory * Stable daily dose(s) for 90 days prior to the day of screening of any of the following antidiabetic drug(s) or combination regime(s): 1

Then on April 30, 2026, the FDA published a Federal Register notice proposing to formally exclude semaglutide, tirzepatide, and liraglutide from the 503B bulk drug substances list

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These can include nausea, diarrhea, constipation, or stomach discomfort, especially in the initial stages of treatment