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It could also reduce astrogliosis and microgliosis in the dentate gyrus region of the hippocampus, prevent the impairment of pro-opiomelanocortin and G-protein-coupled receptor 43 expression caused by T2D, and simultaneously increase the number of NeuN+ and GLP-1R neurons in the hippocampus [Reference de Paiva, da Silva, Mendona, de Souza and Peixoto53]