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10.1016/S0887-8994(97)00026-X Matsumoto J, Ogawa H, Maeyama R, Okudaira K, Shinka T, Kuhara T, Matsumoto I: Successful treatment by direct hemop-erfusion of coma possibly resulting from mitochondrial dysfunction in acute valproate intoxication

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doi: 10.2310/6650.2001.34089 21 BaroneEArenaAHeadEButterfieldDAPerluigiM

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Key challenges include stability, solubility, permeability, absorption, and protecting the active ingredient through the gastrointestinal tract