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It's about understanding their distinct mechanisms and creating a routine where they work in concert, not in conflict
By mimicking GLP-1, tirzepatide increases insulin secretion, reduces glucagon release, and slows gastric emptying
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In addition, a meta-analysis of 1193 patients with baseline SGLT2i use in AMPLITUDE-O and Harmony Outcomes revealed an HR for MACE of 0.78 (95% CI 0.491.24) with SGLT2is and 0.77 (95% CI 0.680.87) without SGLT2is ( P -value for interaction 0.95), and an HR for HHF of 0.34 (95% CI 0.120.96) with SGLT2is and 0.72 (95% CI 0.550.92) without SGLT2is ( P -value for interaction 0.18) [48]
Prez de la Lastra et al., 2021)
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