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Under the iron-rich, ROS-prone conditions characteristic of lesions, this perturbation engages a coordinated program of RCD across intersecting pathwaysnot only ferroptosis but also necroptotic and pyroptotic signalingwhile ferritin handling and mitophagy status further skew redox homeostasis toward irreversible injury in EESCs

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sin embargo, un comit de expertos de la Asociacin Americana de Endocrinlogos Clnicos y del Colegio Americano de Endocrinlogos (AACE/ACE), concluy que la incidencia de CAD es poco frecuente y el riesgo-beneficio favorece el uso de los ISGLT2 sin cambios en sus recomendaciones actuales123,128