Three to six months of concerted effort to make the following changes should be initiated as soon as you become aware that you have, or are at risk for, diabetes: 1) lose weight (if overweight or obese), 2) shift to a healthy, Mediterranean-style or other plant-based diet , 3) increase physical activity and exercise , and 4) incorporate an evidence-based regimen of targeted nutrient supplementation to promote healthy glucose metabolism (see section 14 of this Protocol)
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Cataplerotic TCA cycle flux determined as glutamate-sustained oxygen consumption in primary cultures of astrocytes