21 Liraglutide showed no effect on the hierarchical primary endpoint of time to death, time to rehospitalisation for HF and time-averaged change in N-terminal pro B-type natriuretic peptide (NT-proBNP) from baseline to 180 days (p=0.31), with even an increased risk of emergency department visit, HF hospitalisation or all-cause death events (HR 1.36
For biologics, estimate biosimilar entry timing based on: 351(k) application filing date and development timeline, likely reference product exclusivity end date, Patent Dance status, and the commercial resources of the biosimilar developer
Inflammation Experimental and clinical evidence suggests that NPs may promote inflammatory responses potentially involved in cardiovascular disease progression, particularly atherosclerosis [70] (Fig
We deliberately included options across whey, plant, ready-to-drink, and meal-replacement formats so there is a sensible match whether you tolerate dairy, prefer vegan, or have days when you cannot face solid food at all
McGill et al., 2012